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This is the case of rapamycin, which is unlikely to be administered for prolonged time intervals

Best Pract Res Clin Endocrinol Metab 32(1):1725 Mannaa FA, Abdel-Wahhab KG, Hassan LK, Taher RF, Morsy FA, Fadl NN (2021) Influence of Melissa officinalis methanolic extract on hyperthyroidism in a rat model